bone marrow transplant research paper

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Bone marrow transplant research paper robby leonardi resume

Bone marrow transplant research paper

Muraro Joachim Burman. Perspective 28 Apr Contemporary haploidentical stem cell transplant strategies in children with hematological malignancies Ravi M. Review Article 05 Mar Genetics of donor cell leukemia in acute myelogenous leukemia and myelodysplastic syndrome Lacey Williams Kimberley Doucette Catherine Lai.

Review Article 08 Mar View all issues. Thank you to our reviewers A sincere thank you to all of the reviewers listed here, who took the time to review for Bone Marrow Transplantation in Acknowledging the impact of Covid As a result of the significant disruption that is being caused by the COVID pandemic we are very aware that many researchers will have difficulty in meeting the timelines associated with our peer review process during normal times.

Search Bone Marrow Transplantation. Browse articles. Review Article 21 Jul T-cell replete allogeneic stem cell transplant for mantle cell lymphoma achieves durable disease control, including against TP mutated disease Thomas E. Lew Edward R. Cliff Amit Khot. Correspondence 20 Jul Obituary 19 Jul John Brian Friend Kathryn Leung.

Article 17 Jul Metabolic syndrome and cardiovascular disease after haematopoietic cell transplantation HCT in adults: an EBMT cross-sectional non-interventional study D. Greenfield N. Salooja J. Article Open Access 17 Jul Clinical characteristics and viral load patterns in children with cytomegalovirus gastrointestinal disease after allogeneic hematopoietic stem cell transplantation Hyun Mi Kang Seong Koo Kim Bin Cho. Venetoclax-based salvage therapy followed by Venetoclax and DLI maintenance vs.

Sex still matters Shaun R. Editorial 16 Jul Prognostic value of measurable residual disease at allogeneic transplantation for adults with core binding factor acute myeloid leukemia in complete remission Takaaki Konuma Tadakazu Kondo Masamitsu Yanada. Article 16 Jul COVID and hematopoietic cell transplantation This collection brings together the latest research and insight on the challenges and impact COVID has had on hematopoietic cell transplantation. Collection 24 Jun Bone marrow transplantation represents the technical application of basic immunologic principles to the treatment of a variety of neoplastic and allied disorders that originate in the bone marrow.

The results have improved during the past 15 years, being most striking for the treatment of the acute and chronic leukemias. The promise of autologous bone marrow transplantation for the treatment of leukemias and solid tumors is awaiting the perfection of techniques for the effective removal of residual neoplastic cells as well as more effective therapy. The use of this technique at its present stage of development for the treatment of benign hematologic disorders, which cause severe morbidity ie, thalassemia or sickle cell anemia , is controversial, raises serious ethical issues, and cannot be recommended routinely at this time.

Complications of bone marrow transplantation such as graft rejection, graft-versus-host disease, and opportunistic infections are discussed. Full text is available as a scanned copy of the original print version. Get a printable copy PDF file of the complete article 1. Links to PubMed are also available for Selected References.

These references are in PubMed. This may not be the complete list of references from this article. National Center for Biotechnology Information , U. J Natl Med Assoc. Hardy and E. Copyright and License information Disclaimer. Copyright notice. This article has been cited by other articles in PMC. Abstract Bone marrow transplantation represents the technical application of basic immunologic principles to the treatment of a variety of neoplastic and allied disorders that originate in the bone marrow.

Cytological identification of radiation-chimaeras. Intravenous infusion of bone marrow in patients receiving radiation and chemotherapy. N Engl J Med. Rev Fr Etud Clin Biol. The major histocompatibility complex--genetics and biology. First of three parts. The major histocompatibility complex--genetics and biology second of three parts. The major histocompatibility complex - genetics and biology third of three parts.

Bone marrow transplantation. Bone-marrow transplantation first of two parts. Karnofsky Memorial Lecture. Marrow transplantation for malignant diseases. J Clin Oncol. Autologous bone marrow grafts in dogs treated with lethal doses of cyclophosphamide. Cancer Res. Allogeneic bone marrow transplantation in acute nonlymphocytic leukemia: a pilot study. Immediate medical consequences of nuclear accidents. Lessons from Chernobyl.

Aplastic anemia first of two parts : pathogenesis, diagnosis, treatment, and prognosis. Aplastic anemia second of two parts : pathogenesis, diagnosis, treatment, and prognosis. Current status of bone marrow transplantation for aplastic anemia and acute leukemia. One-hundred-ten patients with aplastic anemia AA treated by marrow transplantation in Seattle. Transplant Proc. Severe aplastic anemia: a prospective study of the effect of early marrow transplantation on acute mortality.

Marrow transplantation for treatment of aplastic anemia. An analysis of factors associated with graft rejection. Marrow transplantation in thirty "untransfused" patients with severe aplastic anemia. Ann Intern Med. Chemotherapy of acute lymphoblastic leukemia in children. Am J Hematol. Prolonged second remissions in childhood acute lymphocytic leukemia: a report from the Childrens Cancer Study Group.

Med Pediatr Oncol. Treatment of acute myelocytic leukemia: a study by cancer and leukemia group B. Bone-marrow ablation and allogeneic marrow transplantation in acute leukemia. Allogeneic bone marrow transplantation for patients with acute nonlymphocytic leukemia. Bone-marrow transplantation for acute leukaemia in first remission. The place of bone-marrow transplantation in acute myelogenous leukaemia.

Allogeneic marrow transplantation for acute nonlymphoblastic leukemia after first relapse. A comparison of marrow transplantation with chemotherapy for children with acute lymphoblastic leukemia in second or subsequent remission.

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A sincere thank you to all of the reviewers listed here, who took the time to review for Bone Marrow Transplantation in The journal could not exist without the knowledge and critical evaluation provided by our reviewers - content is often vastly improved by the suggestions and recommendations they provide.

As a result of the significant disruption that is being caused by the COVID pandemic we are very aware that many researchers will have difficulty in meeting the timelines associated with our peer review process during normal times.

Please do let us know if you need additional time. Our systems will continue to remind you of the original timelines but we intend to be highly flexible at this time. Bone Marrow Transplantation is a Transformative Journal ; authors can publish using the traditional publishing route OR via immediate gold Open Access. Our Open Access option complies with funder and institutional requirements. Advanced search. Skip to main content Thank you for visiting nature.

Welcome to Bone Marrow Transplantation Publishing high quality, peer reviewed original research and reviews addressing all aspects of basic biology and clinical use of haemopoietic cell transplantation. Chimeric antigen receptor T cell therapy in multiple myeloma: promise and challenges Binod Dhakal Parameswaran N. Hari Mehdi Hamadani. Review Article 07 Aug Article 15 May Current issue. Serendipity in medicine and wine Shaun R.

Editorial 08 Jan Tales of the unexpected Shaun R. Editorial 01 Mar Feature Open Access 24 May New autoimmune diseases after autologous hematopoietic stem cell transplantation for multiple sclerosis Richard K. Burt Paolo A. Muraro Joachim Burman. Perspective 28 Apr Contemporary haploidentical stem cell transplant strategies in children with hematological malignancies Ravi M. Review Article 05 Mar Genetics of donor cell leukemia in acute myelogenous leukemia and myelodysplastic syndrome Lacey Williams Kimberley Doucette Catherine Lai.

Review Article 08 Mar View all issues. Thank you to our reviewers A sincere thank you to all of the reviewers listed here, who took the time to review for Bone Marrow Transplantation in Acknowledging the impact of Covid As a result of the significant disruption that is being caused by the COVID pandemic we are very aware that many researchers will have difficulty in meeting the timelines associated with our peer review process during normal times.

Those of donor stem cell origin would be ideal, as they should persist long term in the recipient and mitigate against leukemic relapse. Use of HLA matched sibling donors reduced but did not remove this risk which was higher when non-sibling HLA matched family donors were used.

Haploidentical donors, i. Such a procedure has become more common, especially after the development of conditioning regimens involving cyclophosphamide 21 that appear effective at generating the early expansion of regulatory T cells.

Haploidentical transplantation has provided a unique platform for experimental tolerogenic strategies, with several studies providing convincing evidence that, at least when using the most appropriate donor, the outcome can be very good A recent retrospective study 23 has convincingly documented that it is the patient and disease rather than donor features that affect survival of these patients. However, it is important to acknowledge the fact that the technique of haploidentical transplantation exposes patients to delayed immune reconstitution thus potentially limiting some of the benefits.

Complete removal of T cells can be effective, but leukemic patients then have higher relapse rates, due to the removal of GVL effectors. Reduction in the number of contaminating T cells can help, but is difficult to titrate. Mitigating the risk of relapse, donor lymphocyte infusions 10 have been used and these, following HSC transplantation, have provided long-term curative treatment, particularly for chronic myeloid leukemia. Since T cells in these donor inocula are long lived and likely to contain a number of different clones with specificity for several transplantation antigens, mutant leukemic cells are likely to be targeted as they arise, a situation not replicated when targeted molecular therapy is given, directed against a determinant whose expression can be downregulated by mutation.

The use of cord blood as a source of HSC uncontaminated by primed T cells is practical only for child recipients, as single donations rarely contain sufficient stem cells to achieve engraftment. However, recent data suggests the opportunity to use aryl hydrocarbon antagonists to produce a robust expansion of hematopoietic stem and progenitor cells There are still issues that can limit the applicability of the gene therapy approach.

On one side the modification of HSCs may reduce their capacity to engraft, whilst on the other the modification strategy may require the selection of the gene-corrected cells, thus impacting on the cell yield required to be efficiently transplanted Based on the notion that it is the graft-vs. Whilst radiation was the main component of the pre-transplant conditioning because of its efficacy in eliminating replicating cells, other milder approaches have been used since the end of the 90s.

Furthermore, it was shown that the use of cyclophosphamide soon after HSC infusion could mitigate the incidence of GvHD by increasing the number of regulatory T cells Unfortunately, GvHD remains the most dreadful complication of allografting and when refractory to steroid treatment the associated mortality is dismal. Cellular therapies may provide an alternative to traditional immunosuppressive approaches because they may provide an immunological reprogramming of the patient's inflammatory environment.

Important milestones in this direction have been provided by the use of regulatory T cells 28 and mesenchymal stromal cells MSC. Initially identified as tout-court immunosuppressants 29 , MSC have been recently shown as effective at reprogramming the recipient phagocytic system to control unwanted inflammation This has transplanted into very encouraging clinical experience Leukemias, bone marrow failures, hemoglobinopathies e.

Reducing the incidence and severity of GVHD following HSC transplant remains the biggest challenge for both existing patients and the possibility of extending this treatment to additional diseases. ES and FD drafted the review together. ES concentrating on the historical background and FD on the clinical aspects. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

National Center for Biotechnology Information , U. Journal List Front Immunol v. Front Immunol. Published online Jun 5. Author information Article notes Copyright and License information Disclaimer. This article was submitted to Molecular Innate Immunity, a section of the journal Frontiers in Immunology.

Received Feb 12; Accepted May The use, distribution or reproduction in other forums is permitted, provided the original author s and the copyright owner s are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. This article has been cited by other articles in PMC. Abstract Clinical bone marrow transplantation started in at a time when remarkably little was known about hematopoietic stems cells, immune responses to transplants or the identity of transplant antigens.

Keywords: transplantation, histocompatibility, graft-vs. Introduction The Scuola Superiore d'Immunologia Ruggero Ceppellini Ceppellini School was founded in in Naples by Professor Serafino Zappacosta, to honor the memory and achievements of Professor Ruggero Ceppellini, a giant in the field of HLA genetics, who led an approach to addressing complex scientific questions through national and international collaboration Figure 1. Open in a separate window. Figure 1. Immune Responses to Transplants Hemopoietic stem cell transplantation HSCT is the forerunner of both cell and gene therapies, which depend on slipping potentially foreign components past homeostatic controls limiting cell numbers and immune responses fine-tuned by evolutionary selection for protection against pathogens.

Genetics, Molecular Identity and Function of Transplantation Antigens, Major and Minor George Snell took a systematic genetic approach to enumerating and mapping loci responsible for graft rejection with experiments transplanting skin and tumor grafts between inbred mouse strains, their F1 hybrids and backcross progeny.

Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. References 1. Intravenous infusion of bone marrow in patients receiving radiation and chemotherapy. N Engl J Med. Actively acquired tolerance of foreign cells. Protective effects of implantation of spleen tissue.

Proc Roy Soc Med. Medawar PB. The behaviour and fate of skin autografts and homografts in rabbits: a report to the War Wounds Committee of the Medical Research Council. J Anat. Mitchison NA. Passive transfer of transplantation immunity. Quantitative studies on tissue transplantation immunity. Actively acquired tolerance. Phil Trans Roy Soc B. Kohler G, Milstein C. Continuous cultures of fused cells secreting antibody of predefined specificity.

Hardy RR, Roederer M. Uchida N, Weissman IL. J Exp Med. Comparison of single-dose and escalating-dose regimens of donor lymphocyte infusion for relapse after allografting for chronic myeloid leukemia. Snell GD. Methods for the study of histocompatibility genes. J Genet. Bodmer WF. In memoriam Ruggero Ceppellini — Experimental allotransplantation in man I.

The role of the HLA system in different genetic combinations. Transplant Proc. Janeway CA, Jr. T cell populations with different functions. In vitro cell-mediated immune responses to the male specific H-Y antigen in mice. Y-antigen killing by T cells of women restricted by HLA.

The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens. A modified post-transplant cyclophosphamide PT-CY regimen, following unmanipulated haploidentical bone marrow transplantation, for acute myeloid leukemia: a multicenter study. Selecting the best haploidentical donor. Semin Hematol. Effect of donor characteristics on haploidentical transplantation with posttransplantation cyclophosphamide. Blood Adv. Cell Stem Cell. Haematopoietic stem cell therapy: progress and lessons learned.

Factors for graft- versus -host disease after donor lymphocyte infusions with an escalating dose regimen: lack of association with cell dose. Br J Haematol. Semin Oncol. Umbilical cord blood-derived T regulatory cells to prevent GVHD: kinetics, toxicity profile, and clinical effect.

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